中国医药指南

目的 探究氟马西尼改善丙泊酚无痛胃肠镜检查后患者复苏、认知功能的效果。方法 依据随机数字表法，将2022年1—9月在南昌市第一医院接受无痛胃肠镜检查的80例患者分为两组，每组40例，在患者无痛胃肠镜检查完成后，对照组给予生理盐水（5 ml），观察组给予氟马西尼（0.3～0.5 mg），对比组间睁眼时间、清醒时间、不良反应、复苏和认知功能、应激状态。结果 观察组睁眼时间[（4.83±0.55）min vs.(6.13±1.27)min,P <0.001]、清醒时间[（6.79±1.44）min vs.(9.38±2.16)min,P <0.001]均短于对照组。干预1 h后，两组患者复苏、认知功能评分均高于干预前，观察组评分高于对照组（P <0.05）；两组手术应激指数（SSI）均高于干预前（P <0.05），观察组SSI高于对照组（62.34±3.16 vs. 57.88±1.24,P <0.001）。两组不良反应发生率差异无统计学意义（P> 0.05）。结论 氟马西尼用于丙泊酚无痛胃肠镜检查后，对于患者复苏、认知功能、应激状态及不良反应发生情况方面均有改善作用，在临床应用中具有重要价值。

Objective To investigate the effect of flumazenil in improving patient resuscitation and cognitive function after propofol painless gastroenteroscopy. Methods Based on the random number table method, 80 patients who underwent painless gastroenteroscopy in the First Hospital of Nanchang City from January to September 2022 were divided into two groups of 40 cases each. After the patients' painless gastroenteroscopy was completed, the control group was given saline(5 ml), and the observation group was given flumazenil(0.3-0.5 mg), and the eye-opening time, wakefulness time, and so on were compared between the groups, adverse reactions, resuscitation and cognitive function, and stress. Results The observation group's eye-opening time [(4.83±0.55) min vs.(6.13±1.27) min, P<0.001] and awake time [(6.79±1.44) min vs.(9.38±2.16) min, P<0.001]were shorter than the control group. After 1 h of intervention, the resuscitation and cognitive function scores of patients in both groups were higher than those before intervention, and the scores of the observation group were higher than those of the control group(P<0.05); the surgical stress index(SSI) of both groups were higher than those before intervention(P<0.05), and the SSI of the observation group were higher than those of the control group(62.34±3.16 vs. 57.88±1.24, P<0.001). The difference in the incidence of adverse reactions between the two groups was not statistically significant(P>0.05). Conclusions After flumazenil is used for propofol painless gastroenteroscopy, it has an improved effect on patients in terms of resuscitation, cognitive function, stress and the occurrence of adverse effects, which is of great value in clinical application.